13 RESULTS
COMMENT Charles Duyckaerts was born on 16 December 1951 in Liege, Belgium, and died on Saturday 6 August 2022 in Paris. He was a university professor-hospital practitioner. He directed the neuropathology laboratory on the Pitié Salpêtrière campus in Paris, France
COMMENT Tau aggregates are a “sponge” for numerous biological molecules, including heparan sulfate, proteins, lipids, and nucleic acids such as RNAs. A fundamental question is whether any of these molecules are primary causes of disease by participating in tau se
COMMENT It is with profound sadness that I learned of the death of Professor Peter Davies. What terrible news. Peter was a mentor to many of us. A pioneer in the cholinergic hypothesis, he was quickly interested in tau protein. He then became a leader in the tau
COMMENT comments can be made about the selection of the antibody, the targeted population, and the future.
COMMENT also contributed to this comment. thibaud.lebouvier Luc.Buee 0 CSF tau and the CSF tau/ABeta ratio for
COMMENT This is a nice article. One could ask why calpastatin is downregulated. Since proteasome inhibition may modulate calpain activity, what is the status of the proteasome in JNLP3 mice? Luc.Buee 0 Proteasome inhibition and Tau proteolysis: an unexpected regu
COMMENT We all agree that DNA damage increases with aging. Many proteins described in neurodegenerative disorders may be involved in this process. A key one is once again forgotten: tau. Luc.Buee 0 Nuclear tau, a key player in neuronal DNA protection.
COMMENT It is clear that the role of Cdk5 in neuronal cell death is much more complex than previously believed. Regarding Bruce Lamb's hypothesis about the role of p39, p25, and p10, I'd like to point out respectfully that these subunits may not block c
COMMENT First, we would like to thank Dr Kamali-Moghaddam for his comments. Regarding the methodology, we
COMMENT Since Alzhemed is a disease modifyer, the use of biomarkers by quantification of Abeta in CSF and/or plasma to assess its efficacy in this trial may be a real asset. Luc.Buee 0
COMMENT Pin1 was always considered a cell cycle regulator. This article indicates that Pin1 is likely a key actor in neurons. In fact, there is an up-regulation of Pin1 during neuronal differentiation and a specific tau dephosphorylation on Thr231. 0 Luc.Buee
COMMENT The NMR approach of studying tau protein is opening new perspectives in tau biology and therapeutic strategies of tau aggregation. 0 Luc.Buee
COMMENT This article is mostly technical, and only preliminary data are shown. I realize this may sound severe, but I believe we should all keep this caveat in mind, especially given how we are urged to publish. Having said that, this work is full of promise. It
